An essay by Ben Zimmer of the Visual Thesaurus:
Many people feel quite strongly about moist — there's even a Facebook group called called "I HATE the word MOIST!" with more than 300 members. One Facebooker calls moist "possibly the worst word in the English dictionary," while another says, "I despise the sick, repugnant word!" It's hard to top the aversion felt for moist, but some other Visual Thesaurus "least favorites" can provoke similar reactions: panty/panties, vomit, ointment, and slacks.
It's difficult to find any unifying thread for these words that get people's goat. But much like the enjoyable words on the "favorites" list like serendipity and mellifluous, there's a certain sound/sense combination that sparks these word aversions. Why does moist merit a Facebook group of haters, while hoist and joist go unnnoticed? It's more than just the sound of the word: the disliked words tend to have some basic level of ickiness. As I told the Albany Times Union, this ickiness can have to do with slimy stuff, bodily discharge, or other things that people would prefer not to think about. Icky words include nostril, crud, pus, and pimple. Ointment and goiter share the "oi" sound with moist: there must be something about that diphthong that gets under people's skin.
"Which Words Do You Love and Which Do You Hate?"
Thanks to Boing Boing